로그인 회원가입
icon_bulk_order대량 주문 Acrobiosystems for English
0
장바구니가 비어 있습니다
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > Cathepsin L

Cathepsin L

요약

Name:Cathepsin L
Target Synonym:Cathepsin L1,CATL,CTSL,MEP,EC:3.4.22.15,CTSL1,Major Excreted Protein,Cathepsin L,FLJ31037
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

제품 리스트 구매

일부의 생물활성 데이터

CAL-M52H3-MALS-HPLC
Cathepsin L MALS images

The purity of Mouse Cathepsin L Protein, His Tag (Cat. No. CAL-M52H3) is more than 90% and the molecular weight of this protein is around 35-50 kDa verified by SEC-MALS.

Synonym Name

CTSL1,MEP,CATL,CTSL

Background

Cathepsin L (CTSL1) is also known as major excreted protein (MEP), is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains linked by disulfide bonds. CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. MEP has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. CTSL1 is important for the overall degradation of proteins in lysosomes. The specificity of MEP is close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z - Arg ¨C Arg ¨C NHMec, and no peptidyl - dipeptidase activity. Human Cathepsin L activity is greatest under mildly acidic conditions, from pH 4.5

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
SLV-213 SLV-213; SLV213 Selva Therapeutics Inc Details

This web search service is supported by Google Inc.

totop